Glutaric anhydride → Theophylline

HRID 1156150Notes

Reaction equation

HRID 1156150 reaction equation
[NH2:1][C:2]1[N:3]([CH3:12])[C:4](=[O:11])[N:5]([CH3:10])[C:6](=[O:9])[C:7]=1[NH2:8].[C:13]1(=O)OC(=O)CCC1>>[N:5]1([C:6](=[O:9])[C:7]2[NH:8][CH:13]=[N:1][C:2]=2[N:3]([CH3:12])[C:4]1=[O:11])[CH3:10]

Participants

3

Reactant 2

HCID 7940Glutaric anhydrideHCID 795015,6-Diamino-1,3-dimethyluracil

Product 1

HCID 2153Theophylline

Procedure

Following the method of Cook et al., Res. Comm. Chem. Path. Pharm. 13:497 (1976), 4,5-diamino-1,3-dimethylpyrimidine-2,6-dione is heated with glutaric anhydride to yield the following: ##STR16##

Workup

  1. customto yield the following: ##STR16##

Sources & evidence

ORD record
ord-d917779cf2d84959abc6b38b0cf892d7
Source dataset
uspto-grants-1982_06
Patent number
US04334069

Reaction notes

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