反应详情

A stirred mixture of 2-phenyl-5-methoxy-6,7-dichloro-1-indanone (5.18 g., 16.8 mmol) and pyridine hydrochloride (23.3 g., 202 mmol) is heated at 190° for a period of 2 hrs. and then poured into 300 ml. of cold 2 N hydrochloric acid. Insolubles are collected, dried and crystallized from ethanol to afford 3.7 g. (75% yield) of 2-phenyl-5-hydroxy-6,7-dichloro-1-indanone, m.p. 252°-253.5°.

1. temperatureis heated at 190° for a period of 2 hrs
2. additionand then poured into 300 ml
3. customInsolubles are collected
4. customdried
5. customcrystallized from ethanol
6. customto afford 3.7 g