反应详情

A solution of 33 g of 11-hydroxy-6,11-dihydrodibenz[b,e]thiepin in 400 ml of absolute alcohol is saturated with hydrogen chloride gas at 5° C. for 1/2 hour. The resulting solution is dried with CaCl2, filtered and concentrated in vacuo to an oil which crystallizes upon standing in a refrigerator (10° C.) after 3 days. Recrystallization from cyclohexane provides 27 g of 11-chloro-6,11-dihydrodibenz[b,e]thiepin m.p. 79°-82° C.

1. dry with materialThe resulting solution is dried with CaCl2
2. filtrationfiltered
3. concentrationconcentrated in vacuo to an oil which
4. customcrystallizes
5. customRecrystallization from cyclohexane