p-Toluenesulfonic acid → HCID 12593092, compound

HRID 1156302Notes

Reaction equation

HRID 1156302 reaction equation
[C:1]([CH2:4][C:5]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:6]=1[C:7]([OH:9])=O)(O)=O.Br.[NH2:16][CH2:17][CH2:18][CH2:19][SH:20].C([O-])(=O)C.[Na+].C1(C)C=CC(S(O)(=O)=O)=CC=1>>[Cl:14][C:12]1[CH:11]=[CH:10][C:6]2[C:7](=[O:9])[N:16]3[CH2:17][CH2:18][CH2:19][S:20][C:1]3=[CH:4][C:5]=2[CH:13]=1

Participants

5

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 3340352-(Carboxymethyl)-4-chlorobenzoic acidHCID 517045Sodium AcetateHCID 12218835HCID 12218835, compound

Product 1

HCID 12593092HCID 12593092, compound

Procedure

By following the same procedure as in Example 13 using 0.32 g. of 2-carboxymethyl-4-chlorobenzoic acid, 0.37 g. of 3-aminopropanethiol hydrobromide, 0.172 g. of sodium acetate and 0.3 g. of p-toluensulfonic acid, 0.15 g. of 9-chloro-6-oxo-3,4-dihydro-2H,6H-1,3-thiazino[3,2-b]isoquinoline was obtained.

Sources & evidence

ORD record
ord-991c060f3cdc426e95bb3207d57fca2c
Source dataset
uspto-grants-1982_06
Patent number
US04335129

Reaction notes

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