1,2-Epoxybutane → HCID 12651443, compound

HRID 1156427Notes

Reaction equation

HRID 1156427 reaction equation
[Cl-].[Cl:2][C:3]1[C:8]([CH2:9][P+](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=[C:7]([CH3:29])[C:6]([CH3:30])=[C:5]([O:31][CH3:32])[CH:4]=1.[F:33]/[C:34](=[CH:43]\[CH:44]=[C:45](/[CH3:48])\[CH:46]=O)/[C:35](/[CH3:42])=[CH:36]/[C:37]([O:39][CH2:40][CH3:41])=[O:38].C1OC1CC>CCOCC>[Cl:2][C:3]1[C:8](/[CH:9]=[CH:48]/[C:45](/[CH3:46])=[CH:44]/[CH:43]=[C:34](\[F:33])/[C:35](/[CH3:42])=[CH:36]/[C:37]([O:39][CH2:40][CH3:41])=[O:38])=[C:7]([CH3:29])[C:6]([CH3:30])=[C:5]([O:31][CH3:32])[CH:4]=1

Participants

5

Reactant 3

HCID 78341,2-EpoxybutaneHCID 12651433HCID 12651433, compoundHCID 86736594HCID 86736594, compound

Product 1

HCID 12651443HCID 12651443, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 6.0 g. (12.46 mmol) of 6-chloro-4-methoxy-2,3-dimethylbenzyl triphenylphosphonium chloride and 2.71 g. of ethyl (E,Z,E)-4-fluoro-3,7-dimethyl-8-oxo-2,4,6-octatrienoate in 15 ml. of 1,2-butylene oxide was heated at 110° C. in a sealed tube for 60 hours. The resulting mixture was worked up with ether in the usual manner to give 13.53 g. of crude product. This material was chromatographed on 300 g. of silica gel. Elution with 1:4 ether-petroleum ether yielded 4.65 g. of yellow crystals. Recrystallization of this material from methylene chloride-petroleum ether afforded 1.67 g. (35% yield) of pure ethyl (E,Z,E,E)-9-(6-chloro-4-methoxy-2,3-dimethylphenyl)-4-fluoro-3,7-dimethyl-2,4,6,8-nonatetraenoate as yellow crystals, mp. 126°-128° C.

Workup

  1. additionA mixture of 6.0 g
  2. customto give 13.53 g
  3. customThis material was chromatographed on 300 g
  4. washElution with 1:4 ether-petroleum ether
  5. customyielded 4.65 g
  6. customRecrystallization of this material from methylene chloride-petroleum ether
  7. customafforded 1.67 g

Sources & evidence

ORD record
ord-c9db6f19813843d29b5b957f337c9ace
Source dataset
uspto-grants-1982_06
Patent number
US04335248

Reaction notes

Loading…