Water → HCID 178512684, compound

HRID 1156509Notes

Reaction equation

HRID 1156509 reaction equation
Cl.[NH2:2][C:3]([NH2:5])=[NH:4].[OH-].[Na+].O.Cl[C:10]1[N:15]=[C:14]([Cl:16])[CH:13]=[C:12]([Cl:17])[N:11]=1>CC(C)=O>[Cl:17][C:12]1[CH:13]=[C:14]([Cl:16])[N:15]=[C:10]([NH:4][C:3]([NH2:5])=[NH:2])[N:11]=1

Participants

6

Reactant 4

HCID 962WaterHCID 5742Guanidine HydrochlorideHCID 14798Sodium HydroxideHCID 773782,4,6-Trichloropyrimidine

Product 1

HCID 178512684HCID 178512684, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A solution of 141.8 g (1.48 mole) of guanidine hydrochloride, 59.3 g (1.48 m) of sodium hydroxide and 709 ml of water was added to a solution of 183.4 g (0.74 m) of 2,4,6-trichloropyrimidine in 2127 ml of acetone causing a mild exothermic reaction. After stirring for 1 hour at room temperature, a mixture of solid and oil had formed. Refrigeration caused complete crystallization. The crystals were filtered, then suspended in 1200 ml of water and stirred for 1 hour, filtered, washed with water, then acetone and air dried to give 53.0 g (35%) of 4,6-dichloro-2-guanidinopyrimidine, mp>360°.

Workup

  1. customa mild exothermic reaction
  2. additiona mixture of solid
  3. customoil had formed
  4. customcrystallization
  5. filtrationThe crystals were filtered
  6. stirringstirred for 1 hour
  7. filtrationfiltered
  8. washwashed with water
  9. dry with materialacetone and air dried

Sources & evidence

ORD record
ord-0c3f406cf0e441fd857905df1edb4445
Source dataset
uspto-grants-1982_06
Patent number
US04336254

Reaction notes

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