Guanidine → HCID 178512561, compound

HRID 1156510Notes

Reaction equation

HRID 1156510 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[NH2:10][C:11]([NH2:13])=[NH:12]>O>[NH2:1][C:2]1[N:3]=[C:4]([NH:12][C:11]([NH2:13])=[NH:10])[CH:5]=[C:6]([Cl:8])[N:7]=1

Participants

4

Reactant 2

HCID 3520GuanidineHCID 655222-Amino-4,6-dichloropyrimidine

Product 1

HCID 178512561HCID 178512561, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 12.0 g (0.0732 m) of 2-amino-4,6-dichloropyrimidine and 55.0 g (0.931 mole) of guanidine was heated at 80° for 1.5 hours. The mixture was cooled to room temperature and diluted with water; the white crystalline precipitate was filtered, washed with water then air dried giving 7.22 g (53%) of 2-amino-6-chloro-4-guanidinopyrimidine, mp 220° (dec.).

Workup

  1. temperaturewas heated at 80° for 1.5 hours
  2. filtrationthe white crystalline precipitate was filtered
  3. washwashed with water
  4. customair dried

Sources & evidence

ORD record
ord-0fc4fbcd060941efa01577098328e203
Source dataset
uspto-grants-1982_06
Patent number
US04336254

Reaction notes

Loading…