反应详情

67 g (0.25 mole) of 2-(N-benzylmethylamino)methylcyclohexanone hydrochloride obtained as described in (a) are introduced in the course of 30 minutes, whilst stirring and cooling, into a Grignard solution which has been prepared from 110 g (0.7 mole) of 3-methoxybenzyl chloride, 16.8 g of magnesium and 700 ml of dry ether; stirring is continued for 16 hours at room temperature, the reaction mixture is decomposed with an excess of concentrated ammonium chloride solution, the ether layer is separated off and dried with sodium sulfate, the ether is driven off and the residue is distilled under reduced pressure.

1. additionare introduced in the course of 30 minutes
2. temperaturecooling, into a Grignard solution which
3. stirringstirring
4. customthe ether layer is separated off
5. dry with materialdried with sodium sulfate
6. distillationthe residue is distilled under reduced pressure