HCID 56610644, compound → HCID 20534813, compound

HRID 1156516Notes

Reaction equation

HRID 1156516 reaction equation
C([N:8]1[CH2:14][CH:13]2[CH2:15][CH2:16][CH2:17][CH2:18][C:12]2([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=2)[O:11][CH2:10][CH2:9]1)C1C=CC=CC=1>[Pd].C(O)(=O)C>[CH3:26][O:25][C:21]1[CH:20]=[C:19]([C:12]23[CH2:18][CH2:17][CH2:16][CH2:15][CH:13]2[CH2:14][NH:8][CH2:9][CH2:10][O:11]3)[CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 1

HCID 56610644HCID 56610644, compound

Product 1

HCID 20534813HCID 20534813, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

16 g (0.045 mole) of 4-benzyl-9a-(3-methoxyphenyl)-perhydro-1,4-benzoxazepine (boiling point 240°-260° C./0.07 mbar), prepared by methods similar to that of Example 1, are hydrogenated in the conventional manner with a palladium/charcoal catalyst (5 g of 5% strength Pd on charcoal) in glacial acetic acid; after filtration and distillation, 8.8 g (75% of theory) of 9a-(3-methoxyphenyl)-perhydro-1,4-benzoxazepine, of boiling point 180°-185° C./0.07 mbar, are obtained.

Workup

  1. filtrationafter filtration and distillation, 8.8 g (75% of theory) of 9a-(3-methoxyphenyl)-perhydro-1,4-benzoxazepine
  2. customof boiling point 180°-185° C./0.07 mbar, are obtained

Sources & evidence

ORD record
ord-c69aa9af02074100bd8bbb071410cf98
Source dataset
uspto-grants-1982_06
Patent number
US04336263

Reaction notes

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