反应详情

A mixture of 1.66 g. (10 mmole) of 4-(2,3-epoxy-1-propoxy)-phenol and 4.5 g. (30 mmole) of 1-methyl-2-phenoxyethylamine was heated at 90° C. for 3 hours. The residue was triturated with ether and filtered. Recrystallization from ethyl acetate to which a little methanol was added gave 1-(1-methyl-2-phenoxyethylamino)-3-(4-hydroxyphenoxy)-2-propanol; mp 173°-175° C.

1. additionA mixture of 1.66 g
2. customThe residue was triturated with ether
3. filtrationfiltered
4. customRecrystallization from ethyl acetate to which a little methanol
5. additionwas added