HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Phenoxy-2-propanamine → 1-(1-Methyl-2-phenoxyethylamino)-3-(4-hydroxyphenoxy)-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Phenoxy-2-propanamine | HCID 37087 | — |
| Reactant | 4-(2,3-Epoxy-1-propoxy)-phenol | HCID 12874984 | — |
| Product | 1-(1-Methyl-2-phenoxyethylamino)-3-(4-hydroxyphenoxy)-2-propanol | HCID 12855743 | — |
Reaction Steps
A mixture of 1.66 g. (10 mmole) of 4-(2,3-epoxy-1-propoxy)-phenol and 4.5 g. (30 mmole) of 1-methyl-2-phenoxyethylamine was heated at 90° C. for 3 hours. The residue was triturated with ether and filtered. Recrystallization from ethyl acetate to which a little methanol was added gave 1-(1-methyl-2-phenoxyethylamino)-3-(4-hydroxyphenoxy)-2-propanol; mp 173°-175° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04336261 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-6d8498f4a1da4aca9773ea4034d9707e |
| Source note | uspto-grants-1982_06 |