Hydroxyamine hydrochloride → HCID 12960032, compound

HRID 1156527Notes

Reaction equation

HRID 1156527 reaction equation
[C:1]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][C:4]([C:7]([O:11]C)=[CH:8][C:9]#[N:10])=[CH:3][CH:2]=1.C1(C2C=CC=CC=2)C=CC(C(OC)(OC)CC#[N:28])=CC=1.Cl.NO.C[O-].[Na+]>CO>[C:1]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][C:4]([C:7]2[O:11][N:10]=[C:9]([NH2:28])[CH:8]=2)=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 443297Hydroxyamine hydrochlorideHCID 10942334Sodium MethoxideHCID 12960031HCID 12960031, compoundHCID 54142171HCID 54142171, compound

Product 1

HCID 12960032HCID 12960032, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-(4-Biphenylyl)-3-methoxyacrylonitrile plus 3-(4-biphenylyl)-3,3-dimethoxypropionitrile (2.9 grams as a mixture from example 6), hydroxylamine hydrochloride (4.7 grams), and sodium methoxide (11.9 grams) were mixed in 500 ml. of methanol and the reaction mixture refluxed for 48 hours. The methanol was then evaporated, water added, the product separated by filtration, yield 1.2 grams.

Workup

  1. customThe methanol was then evaporated
  2. additionwater added
  3. customthe product separated by filtration, yield 1.2 grams

Sources & evidence

ORD record
ord-ef21a385cccd4c418e0368e87ffd91e6
Source dataset
uspto-grants-1982_06
Patent number
US04336264

Reaction notes

Loading…