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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1156531Generated: October 31, 2026

Ammonium Hydroxide → 5-(4-tert-BUTYLPHENYL)-3-ISOXAZOLECARBOXAMIDE

https://huagongshe.com/reaction/1156531

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmonium HydroxideHCID 14923—
ReactantEthyl 5-(4-tert-butylphenyl)-1,2-oxazole-3-carboxylateHCID 20534825—
SolventWaterHCID 962—
Product5-(4-tert-BUTYLPHENYL)-3-ISOXAZOLECARBOXAMIDEHCID 20534829—

Reaction Steps

Ethyl 5-(4-tert-butylphenyl)-3-isoxazolecarboxylate (25 grams) was mixed with 1 liter of concentrated ammonium hydroxide, and the reaction mixture stirred overnight (about 18 hours) at room temperature. The reaction mixture was then poured into 1 liter of water. The product precipitated and was separated by filtration, yield, 34 grams. The structure of the product was confirmed by NMR.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04336264
Source datasetuspto-grants-1982_06
ORD IDord-310fee898a5f45d29ad52811917a6b0e
Source noteuspto-grants-1982_06