Ammonium Hydroxide → 5-(4-tert-BUTYLPHENYL)-3-ISOXAZOLECARBOXAMIDE

HRID 1156531Notes

Reaction equation

HRID 1156531 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][N:14]=[C:13]([C:16]([O:18]CC)=O)[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[NH4+:22]>O>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[O:15][N:14]=[C:13]([C:16]([NH2:22])=[O:18])[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 20534825Ethyl 5-(4-tert-butylphenyl)-1,2-oxazole-3-carboxylate

Product 1

HCID 205348295-(4-tert-BUTYLPHENYL)-3-ISOXAZOLECARBOXAMIDE

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethyl 5-(4-tert-butylphenyl)-3-isoxazolecarboxylate (25 grams) was mixed with 1 liter of concentrated ammonium hydroxide, and the reaction mixture stirred overnight (about 18 hours) at room temperature. The reaction mixture was then poured into 1 liter of water. The product precipitated and was separated by filtration, yield, 34 grams. The structure of the product was confirmed by NMR.

Workup

  1. customThe product precipitated
  2. customwas separated by filtration
  3. customyield

Sources & evidence

ORD record
ord-310fee898a5f45d29ad52811917a6b0e
Source dataset
uspto-grants-1982_06
Patent number
US04336264

Reaction notes

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