3-(4-Fluorophenyl)-1,2-oxazol-5-amine → HCID 12960069, compound

HRID 1156535Notes

Reaction equation

HRID 1156535 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[C:11]([NH2:13])[O:10][N:9]=2)=[CH:4][CH:3]=1.[Cl:14][C:15]1[CH:25]=[CH:24][CH:23]=[CH:22][C:16]=1[C:17]([N:19]=[C:20]=[O:21])=[O:18]>C(OCC)(=O)C>[Cl:14][C:15]1[CH:25]=[CH:24][CH:23]=[CH:22][C:16]=1[C:17]([NH:19][C:20]([NH:13][C:11]1[O:10][N:9]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)[CH:12]=1)=[O:21])=[O:18]

Participants

4

Reactant 2

HCID 20603323-(4-Fluorophenyl)-1,2-oxazol-5-amineHCID 99423112-Chlorobenzoyl isocyanate

Product 1

HCID 12960069HCID 12960069, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

3-(4-Fluorophenyl)-5-aminoisoxazole (250 g.) was combined with 300 g. of 2-chlorobenzoyl isocyanate in 50 ml. of ethyl acetate. The reaction mixture was stirred overnight (about 17 hours) and the resulting solid was filtered, washed with ethanol, ether, and then dried, m.p., 200°-202° C.

Workup

  1. filtrationthe resulting solid was filtered
  2. washwashed with ethanol, ether
  3. customdried
  4. custom200°-202° C.

Sources & evidence

ORD record
ord-fd9cae1f2a7d45559ffaa0502cdf076f
Source dataset
uspto-grants-1982_06
Patent number
US04336264

Reaction notes

Loading…