Trichloroacetyl chloride → HCID 12851597, compound

HRID 1156713Notes

Reaction equation

HRID 1156713 reaction equation
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1.[Cl:11][C:12]([Cl:17])([Cl:16])[C:13](Cl)=[O:14]>C1(C)C(C)=CC=CC=1>[Cl:11][C:12]([Cl:17])([Cl:16])[C:13]([NH:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1)=[O:14]

Participants

4

Reactant 2

HCID 6420Trichloroacetyl chlorideHCID 6028483-(Trichloromethyl)-1,2,4-thiadiazol-5-amine

Product 1

HCID 12851597HCID 12851597, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Conditions

Temperature
120 °C

Procedure

To a solution of 10.9 grams (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole in 200 milliliters xylene at 110° C. was added 18.2 grams (0.1 mole) trichloroacetyl chloride over 0.5 hour. After heating for an additional 20 hours at 120° C., the low boiling materials were distilled in vacuo to leave 15.8 grams (87% yield) of pure product as residue; m.p. 157.7° C.

Workup

  1. distillationthe low boiling materials were distilled in vacuo

Sources & evidence

ORD record
ord-93c641eaa7384ce0a823967cc3ceb706
Source dataset
uspto-grants-1982_06
Patent number
US04337081

Reaction notes

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