Chloroacetyl chloride → HCID 12851599, compound

HRID 1156714Notes

Reaction equation

HRID 1156714 reaction equation
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1.[Cl:11][CH2:12][C:13](Cl)=[O:14]>C1(C)C(C)=CC=CC=1>[Cl:11][CH2:12][C:13]([NH:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1)=[O:14]

Participants

4

Reactant 2

HCID 6577Chloroacetyl chlorideHCID 6028483-(Trichloromethyl)-1,2,4-thiadiazol-5-amine

Product 1

HCID 12851599HCID 12851599, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Conditions

Temperature
-10 °C

Procedure

A solution of 10.9 grams (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 11.3 grams (0.1 mole) chloroacetyl chloride in 200 milliliters xylene was refluxed at about 140° C. for 20 hours. Upon cooling the reaction mixture to -10° C., 10.7 grams (73% yield) pure product precipitated; m.p. 146.0° C.

Sources & evidence

ORD record
ord-1ebede772682447a8e924eec0c2d696f
Source dataset
uspto-grants-1982_06
Patent number
US04337081

Reaction notes

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