HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → HCID 12851600, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 3-(Trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 602848 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | HCID 12851600 | HCID 12851600 | 86% |
Reaction Steps
A solution of 10.9 grams (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 14.0 grams (0.18 mole) acetyl chloride in 200 milliliters xylene was refluxed at about 140° C. for 15 hours. The product precipitated (11.2 grams, 86% yield) after concentration in vacuo to approximately 50% of the original volume. A pure product of m.p. 193° C. was obtained by recrystallization from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04337081 |
| Source dataset | uspto-grants-1982_06 |
| ORD ID | ord-3b1ca967e5734e3f8a2ec322a1ddc2a8 |
| Source note | uspto-grants-1982_06 |