Acetyl chloride → HCID 12851600, compound

HRID 1156715Notes

Reaction equation

HRID 1156715 reaction equation
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1.[C:11](Cl)(=[O:13])[CH3:12]>C1(C)C(C)=CC=CC=1>[C:11]([NH:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1)(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 6028483-(Trichloromethyl)-1,2,4-thiadiazol-5-amine

Product 1

HCID 12851600HCID 12851600, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A solution of 10.9 grams (0.05 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 14.0 grams (0.18 mole) acetyl chloride in 200 milliliters xylene was refluxed at about 140° C. for 15 hours. The product precipitated (11.2 grams, 86% yield) after concentration in vacuo to approximately 50% of the original volume. A pure product of m.p. 193° C. was obtained by recrystallization from ethanol.

Workup

  1. customThe product precipitated (11.2 grams, 86% yield)
  2. concentrationafter concentration in vacuo to approximately 50% of the original volume
  3. customA pure product of m.p. 193° C. was obtained by recrystallization from ethanol

Sources & evidence

ORD record
ord-3b1ca967e5734e3f8a2ec322a1ddc2a8
Source dataset
uspto-grants-1982_06
Patent number
US04337081

Reaction notes

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