HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1156717Generated: October 25, 2026
Trichloroacetyl chloride → 5-(N-Methyl-Trichloroacetamido)-3-Trichloromethyl-1,2,4-Thiadiazole
https://huagongshe.com/reaction/1156717
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trichloroacetyl chloride | HCID 6420 | — |
| Reactant | N-Methyl-3-(trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 13150493 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-(N-Methyl-Trichloroacetamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 12851602 | 92% |
Reaction Steps
A solution of 5.8 grams (0.02 mole) 5-methylamino-3-trichloromethyl-1,2,4-thiadiazole and 9.0 grams (0.05 mole) trichloroacetyl chloride in 200 milliliters toluene was refluxed at about 110° C. for 20 hours. Upon cooling to -10° C., 2.7 grams pure product precipitated; m.p. 223° C. An additional 6.0 grams product was isolated by removal of the low boiling materials in vacuo. Total yield was 92%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04337081 |
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| Source dataset | uspto-grants-1982_06 |
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| ORD ID | ord-36de979bf96c461c9ee5e39d26fdcd9c |
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| Source note | uspto-grants-1982_06 |
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