Trichloroacetyl chloride → HCID 12851603, compound

HRID 1156718Notes

Reaction equation

HRID 1156718 reaction equation
[NH:1]([C:8]1[S:12][N:11]=[C:10]([C:13]([Cl:16])([Cl:15])[Cl:14])[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:17][C:18]([Cl:23])([Cl:22])[C:19](Cl)=[O:20]>C1(C)C=CC=CC=1>[C:2]1([N:1]([C:8]2[S:12][N:11]=[C:10]([C:13]([Cl:16])([Cl:15])[Cl:14])[N:9]=2)[C:19](=[O:20])[C:18]([Cl:23])([Cl:22])[Cl:17])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6420Trichloroacetyl chlorideHCID 13360534HCID 13360534, compound

Product 1

HCID 12851603HCID 12851603, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 14.7 grams (0.05 mole) 5-anilino-3-trichloromethyl-1,2,4-thiadiazole and 18.0 grams (0.1 mole) trichloroacetyl chloride in 200 milliliters toluene was refluxed at about 110° C. for 20 hours. After removal of the low boiling material in vacuo, the resulting residue was recrystallized from benzene to give 20.0 grams (91% yield) pure product; m.p. 158° C.

Workup

  1. customAfter removal of the low boiling material in vacuo
  2. customthe resulting residue was recrystallized from benzene

Sources & evidence

ORD record
ord-e59dcb71c7134e9896703f33c1680479
Source dataset
uspto-grants-1982_06
Patent number
US04337081

Reaction notes

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