Potassium Hydroxide → HCID 136061479, compound

HRID 1156722Notes

Reaction equation

HRID 1156722 reaction equation
[OH-:1].[K+].C(S[C:11]1[CH:16]=[N:15][NH:14][C:13](=[O:17])[N:12]=1)C1C=CC=CC=1.S(O)(O)(=O)=O.[NH2:23]O>C(O)C.O>[OH:1][NH:23][C:11]1[CH:16]=[N:15][NH:14][C:13](=[O:17])[N:12]=1

Participants

6

Reactant 3

HCID 14797Potassium HydroxideHCID 159255Hydroxylamine, sulfate (1:1)HCID 20533653HCID 20533653, compound

Product 1

HCID 136061479HCID 136061479, compoundYield 115.9%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of potassium hydroxide (2.02 g) in a mixture of ethanol (50 ml) and water (10 ml), 5-benzylthio-2,3-dihydro-1,2,4-triazin-3-one (6.58 g) and hydroxylamine sulfate (2.95 g) were added, and the resultant mixture was refluxed for 5 hours. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The residue was recrystallized from water to give 5-hydroxyamino-3-oxo-2,3-dihydro-1,2,4-triazine (Ic) (3.34 g) as pale yellow crystals. Yield, 87.1%.

Workup

  1. additionwere added
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was recrystallized from water

Sources & evidence

ORD record
ord-50edc28140ae4c9e81566278e6062654
Source dataset
uspto-grants-1982_06
Patent number
US04337082

Reaction notes

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