Acrylonitrile → Mls003106934

HRID 1156750Notes

Reaction equation

HRID 1156750 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[C:8]#[N:9])[CH:2]=1.[C:16](#[N:19])[CH:17]=[CH2:18]>>[C:8]([C:7]([C:3]1[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=1)([N:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1)[CH2:18][CH2:17][C:16]#[N:19])#[N:9]

Participants

3

Reactant 2

HCID 7855AcrylonitrileHCID 303572(Morpholin-4-yl)(pyridin-3-yl)acetonitrile

Product 1

HCID 301902Mls003106934

Procedure

Leete et al. [J. Org. Chem. 37, 4465-6 (1972)] shows the reaction of 2-(3-pyridinyl)-2-(4-morpholinyl)ethanenitrile with acrylonitrile to produce 4-cyano-4-(3-pyridinyl)-4-(4-morpholinyl)butanenitrile and its conversion by heating it with acetic acid, water and tetrahydrofuran to 4-oxo-4-(3-pyridinyl)butanenitrile.

Sources & evidence

ORD record
ord-648ea2fc8cff43e3a6a16eb5b4bf882b
Source dataset
uspto-grants-1982_06
Patent number
US04337253

Reaction notes

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