2-Piperidone → HCID 20469880, compound

HRID 1156774Notes

Reaction equation

Cl[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8].[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15]>>[OH:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C:10]1=[O:15]

Participants

Reactant 2

HCID 126652-Piperidone

HCID 748286-Chloro-1-hexanol

Product 1

HCID 20469880HCID 20469880, compound

Procedure

In like manner, 6-chloro-1-hexanol is reacted with 2-piperidone to produce 1-(6-hydroxy-1-hexyl)-2-piperidone. The latter is reacted with methanesulfonyl chloride in methylene chloride in the presence of one equivalent of triethylamine to yield 1-(6-methanesulfonyloxy-1-hexyl)-2-piperidone.

Sources & evidence

ORD record: ord-dbbaa5c2339e47318e0524fdccb5815d
Source dataset: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04337250

Reaction notes

Loading…