Hydrochloric Acid → HCID 12850249, compound

HRID 1156791Notes

Reaction equation

HRID 1156791 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:19])[C:9]1[CH:14]=[CH:13][C:12]([O:15]C)=[C:11]([CH3:17])[C:10]=1[CH3:18].[Al+3].[Cl-].[Cl-].[Cl-].Cl>C1C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:19])[C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([CH3:17])[C:10]=1[CH3:18]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6451240Aluminum(III) ChlorideHCID 12850248HCID 12850248, compound

Product 1

HCID 12850249HCID 12850249, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a solution of 42 g (0.163 m) of 2'-fluoro-4-methoxy-2,3-dimethylbenzophenone of Example 1A in 350 ml of dry benzene, 43.5 g (0.326 m) of AlCl3 is added. The mixture is refluxed 21 hours, poured onto 120 ml concentrated HCl and ice and extracted with ether. The ether extract is washed with water, dried (Na2CO3) and evaporated to give pure 2'-fluoro-4-hydroxy-2,3-dimethylbenzophenone, 39.4 g (98%). An analytical sample is recrystallized from ethanol/H2O, m.p. 131°-132° C.

Workup

  1. temperatureThe mixture is refluxed 21 hours
  2. extractionextracted with ether
  3. extractionThe ether extract
  4. washis washed with water
  5. dry with materialdried (Na2CO3)
  6. customevaporated

Sources & evidence

ORD record
ord-382f3bc590fa44c2a26051899eae8122
Source dataset
uspto-grants-1982_06
Patent number
US04337261

Reaction notes

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