6-Chloro-1,2-dihydro-2-oxocyclohepta[b]pyrrole-3-carboxylic acid ethyl ester → 6-Chloro-1,2-dihydro-2-oxocyclohepta[b]pyrrole-3-carboxylic acid

HRID 1156830Notes

Reaction equation

HRID 1156830 reaction equation
C([O:3][C:4]([C:6]1[C:10](=[O:11])[NH:9][C:8]2=[CH:12][CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:7]=12)=[O:5])C>[OH-].[Na+]>[Cl:17][C:14]1[CH:15]=[CH:16][C:7]2[C:8](=[CH:12][CH:13]=1)[NH:9][C:10](=[O:11])[C:6]=2[C:4]([OH:5])=[O:3]

Participants

3

Reactant 1

HCID 128526786-Chloro-1,2-dihydro-2-oxocyclohepta[b]pyrrole-3-carboxylic acid ethyl ester

Product 1

HCID 128526876-Chloro-1,2-dihydro-2-oxocyclohepta[b]pyrrole-3-carboxylic acid

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

6-Chloro-1,2-dihydro-2-oxocyclohepta[b]pyrrole-3-carboxylic acid ethyl ester (1.0 g, described in example 9) was hydrolyzed with 2 N aqueous NaOH (20 ml) under the conditions described for the hydrolysis in example 14 to give 6-chloro-1,2-dihydro-2-oxocyclohepta[b]pyrrole-3-carboxylic acid; mp 227° C. (dec); nmr (DMSO-d6) δ7.39-9.8 (m, 4H), 12.4 (s, 2H).

Workup

  1. customdescribed for the hydrolysis in example 14

Sources & evidence

ORD record
ord-46ce011c966d4dc1a71111239d2fe3e9
Source dataset
uspto-grants-1982_06
Patent number
US04337265

Reaction notes

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