Sodium Hydroxide → HCID 86738454, compound

Participants

Reaction Steps

4.0 g of 2-[4-(3-trifluoromethylphenoxy)butyl]oxirane-2-carboxylic acid ethyl ester, 12 ml of 1 N sodium hydroxide solution and 16 ml of tetrahydrofuran are stirred for 2 hours at room temperature. The solution which has formed is concentrated to one half of its volume in vacuo and is then extracted 2 times with 50 ml of diethyl ether each time. On standing a precipitate crystallizes out of the aqueous solution, which is filtered off and washed with little water and diethyl ether. 2.44 g of the title compound of m.p. 94° to 97° C. are obtained by gradual concentration of the filtrates to a small volume.

Provenance & Evidence