Sodium Hydroxide → HCID 86738454, compound

HRID 1156846Notes

Reaction equation

HRID 1156846 reaction equation
C([O:3][C:4]([C:6]1([CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=2)[CH2:8][O:7]1)=[O:5])C.[OH-].[Na+:25]>O1CCCC1>[F:22][C:20]([F:21])([F:23])[C:16]1[CH:15]=[C:14]([CH:19]=[CH:18][CH:17]=1)[O:13][CH2:12][CH2:11][CH2:10][CH2:9][C:6]1([C:4]([O-:5])=[O:3])[CH2:8][O:7]1.[Na+:25]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 15291200HCID 15291200, compound

Product 1

HCID 86738454HCID 86738454, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4.0 g of 2-[4-(3-trifluoromethylphenoxy)butyl]oxirane-2-carboxylic acid ethyl ester, 12 ml of 1 N sodium hydroxide solution and 16 ml of tetrahydrofuran are stirred for 2 hours at room temperature. The solution which has formed is concentrated to one half of its volume in vacuo and is then extracted 2 times with 50 ml of diethyl ether each time. On standing a precipitate crystallizes out of the aqueous solution, which is filtered off and washed with little water and diethyl ether. 2.44 g of the title compound of m.p. 94° to 97° C. are obtained by gradual concentration of the filtrates to a small volume.

Workup

  1. customThe solution which has formed
  2. concentrationis concentrated to one half of its volume in vacuo
  3. extractionis then extracted 2 times with 50 ml of diethyl ether each time
  4. customcrystallizes out of the aqueous solution, which
  5. filtrationis filtered off
  6. washwashed with little water and diethyl ether

Sources & evidence

ORD record
ord-e68fd5e4aa9e41b3b21b3ffc81f7fdc8
Source dataset
uspto-grants-1982_06
Patent number
US04337267

Reaction notes

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