反应详情

To a solution of 1.7 g of 5-chloroanthranilic acid in 40 ml of pyridine is added a solution of 2.6 g of 3,4,5-trimethoxybenzoylchloride in tetrahydrofuran under cooling, and the mixture is stirred at room temperature for 2 hours and then heated to 80° C. for 30 minutes. The reaction mixture is concentrated under a reduced pressure and to the residue is added water. The precipitated crystals are recrystallized from acetone to obtain 1.4 g of N-(3,4,5-trimethoxybenzoyl)-5-chloroanthranilic acid as colorless needles.

1. temperatureunder cooling
2. temperatureheated to 80° C. for 30 minutes
3. concentrationThe reaction mixture is concentrated under a reduced pressure and to the residue
4. additionis added water
5. customThe precipitated crystals are recrystallized from acetone