反应详情

In a mixture of 30 ml of chloroform and 3 ml of triethylamine is dissolved 3.4 g of 5-chloroanthranilic acid. To this solution is added a solution of 4.5 g of 3,4-dimethoxycinnamoylchloride in chloroform, and the mixture is heated under reflux for 2 hours. The reaction mixture is concentrated under a reduced pressure, and to the residue is added water and hydrochloric acid then added to make the mixture weakly acidic. The precipitated crystals are collected by filtration and recrystallized from ethanol to obtain 3.1 g of N-(3,4-dimethoxycinnamoyl)-5-chloroanthranilic acid as pale yellow needles.

1. temperaturethe mixture is heated
2. temperatureunder reflux for 2 hours
3. concentrationThe reaction mixture is concentrated under a reduced pressure
4. additionto the residue is added water and hydrochloric acid
5. additionthen added
6. filtrationThe precipitated crystals are collected by filtration
7. customrecrystallized from ethanol