Sodium Cyanide → 1-(4-Flurophenyl)isoquinoline-5-acetonitrile

HRID 1156878Notes

Reaction equation

HRID 1156878 reaction equation
[C-:1]#[N:2].[Na+].[F:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:20]3[C:15](=[C:16]([CH2:21]Cl)[CH:17]=[CH:18][CH:19]=3)[CH:14]=[CH:13][N:12]=2)=[CH:7][CH:6]=1>>[F:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:20]3[CH:19]=[CH:18][CH:17]=[C:16]([CH2:21][C:1]#[N:2])[C:15]=3[CH:14]=[CH:13][N:12]=2)=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 8929Sodium CyanideHCID 12851836HCID 12851836, compound

Product 1

HCID 127989611-(4-Flurophenyl)isoquinoline-5-acetonitrile

Procedure

Sodium cyanide and 1-(4-fluorophenyl)-5-chloromethylisoquinoline were reacted in the same way as in step (b) in Example 2 to afford 1-(4-flurophenyl)isoquinoline-5-acetonitrile having a melting point of 136° to 136.5° C.

Sources & evidence

ORD record
ord-1019ff16f32548b1a9af4579007a1d27
Source dataset
uspto-grants-1982_06
Patent number
US04337256

Reaction notes

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