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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1156882Generated: October 30, 2026

1-(4-Chlorophenyl)isoquinoline-5-acetonitrile → 1-(4-Methoxyphenyl)isoquinoline-5-acetonitrile

https://huagongshe.com/reaction/1156882

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(4-Chlorophenyl)isoquinoline-5-acetonitrileHCID 12851828—
ReactantHCID 12851837HCID 12851837—
Product1-(4-Methoxyphenyl)isoquinoline-5-acetonitrileHCID 12851838—

Reaction Steps

1-(4-Methoxyphenyl)-5-methylisoquinoline was reacted successively in the same way as in steps (d) and (e) of Example 1 to afford 1-(4-methoxyphenyl)isoquinoline-5-acetonitrile as slightly yellow scales having a melting point of 130.5° to 132.0° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04337256
Source datasetuspto-grants-1982_06
ORD IDord-4e3ddcd749b6466da3f0f838f924f74c
Source noteuspto-grants-1982_06