1-Cyclohexyl-5-chloroisoquinoline → 1-Cyclohexyl-5-cyanoisoquinoline

HRID 1156917Notes

Reaction equation

HRID 1156917 reaction equation
[CH:1]1([C:7]2[C:16]3[C:11](=[C:12](Cl)[CH:13]=[CH:14][CH:15]=3)[CH:10]=[CH:9][N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cu](C#N)[C:19]#[N:20]>CN(P(N(C)C)(N(C)C)=O)C>[CH:1]1([C:7]2[C:16]3[C:11](=[C:12]([C:19]#[N:20])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[CH:9][N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 205338961-Cyclohexyl-5-chloroisoquinolineHCID 178418260HCID 178418260, compound

Product 1

HCID 128518511-Cyclohexyl-5-cyanoisoquinoline

Reagents, catalysts & solvents 1

HCID 12679HexamethylphosphoramideSolvent

Procedure

1-Cyclohexyl-5-chloroisoquinoline, copper cyanide and hexamethylphosphotriamide were reacted in the same way as in step (d) of Example 13 to afford 1-cyclohexyl-5-cyanoisoquinoline having a melting point of 94.7° C.

Sources & evidence

ORD record
ord-5eb41e5b8d794b9faa843c94795cf8f2
Source dataset
uspto-grants-1982_06
Patent number
US04337256

Reaction notes

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