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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1156917Generated: November 1, 2026

1-Cyclohexyl-5-chloroisoquinoline → 1-Cyclohexyl-5-cyanoisoquinoline

https://huagongshe.com/reaction/1156917

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Cyclohexyl-5-chloroisoquinolineHCID 20533896—
ReactantHCID 178418260HCID 178418260—
SolventHexamethylphosphoramideHCID 12679—
Product1-Cyclohexyl-5-cyanoisoquinolineHCID 12851851—

Reaction Steps

1-Cyclohexyl-5-chloroisoquinoline, copper cyanide and hexamethylphosphotriamide were reacted in the same way as in step (d) of Example 13 to afford 1-cyclohexyl-5-cyanoisoquinoline having a melting point of 94.7° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04337256
Source datasetuspto-grants-1982_06
ORD IDord-5eb41e5b8d794b9faa843c94795cf8f2
Source noteuspto-grants-1982_06