Phosphorus oxychloride → HCID 12851852, compound

HRID 1156918Notes

Reaction equation

HRID 1156918 reaction equation
[CH:1]1([C:7]2[C:16]3[C:11](=[C:12]([CH2:17]O)[CH:13]=[CH:14][CH:15]=3)[CH:10]=[CH:9][N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.P(Cl)(Cl)([Cl:21])=O>>[CH:1]1([C:7]2[C:16]3[C:11](=[C:12]([CH2:17][Cl:21])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[CH:9][N:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 20533887HCID 20533887, compound

Product 1

HCID 12851852HCID 12851852, compound

Procedure

1-Cyclohexyl-5-hydroxymethylisoquinoline and phosphorus oxychloride were reacted in the same way as in step (g) of Example 13 to afford 1-cyclohexyl-5-chloromethylisoquinoline having a melting point of 88.4° to 89.4° C.

Sources & evidence

ORD record
ord-dc0e69c0af604d11bd81513b2f8cbf06
Source dataset
uspto-grants-1982_06
Patent number
US04337256

Reaction notes

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