1-Phenyl-5-methoxycarbonylisoquinoline → 1-n-Propylisoquinoline-5-acetonitrile

HRID 1156930Notes

Reaction equation

HRID 1156930 reaction equation
[C:1]1([C:7]2[C:16]3[C:11](=[C:12]([C:17](OC)=O)[CH:13]=[CH:14][CH:15]=3)[CH:10]=[CH:9][N:8]=2)[CH:6]=[CH:5]C=CC=1.C1([C:27]2C3C(=C(CO)C=CC=3)C=C[N:28]=2)C=CC=CC=1>>[CH2:1]([C:7]1[C:16]2[CH:15]=[CH:14][CH:13]=[C:12]([CH2:17][C:27]#[N:28])[C:11]=2[CH:10]=[CH:9][N:8]=1)[CH2:6][CH3:5]

Participants

3

Reactant 2

HCID 128518481-Phenyl-5-methoxycarbonylisoquinolineHCID 12851849HCID 12851849, compound

Product 1

HCID 205338731-n-Propylisoquinoline-5-acetonitrile

Procedure

1-Amino-2-(2-hydroxymethylphenyl)ethane and butyryl chloride were successively reacted in the same way as in steps (b) and (c) of Example 12 to afford 1-butyrylamino-2-(2-hydroxymethylphenyl)ethane as an oil. The product was successively reacted in the same way as in steps (d), (e), (f) and (g) of Example 12 to afford 1-n-propylisoquinoline-5-acetonitrile.

Sources & evidence

ORD record
ord-c4c04884ced14733941523b6c5a1de4e
Source dataset
uspto-grants-1982_06
Patent number
US04337256

Reaction notes

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