2-Chlorobenzoyl chloride → HCID 12851811, compound

HRID 1156940Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10].[Cl:11][C:12]1[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14](Cl)=[O:15]>>[Cl:11][C:12]1[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=1[C:14]([NH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10])=[O:15]

Participants

Reactant 2

HCID 691102-Chlorobenzoyl chloride

HCID 20638682-Methylphenethylamine

Product 1

HCID 12851811HCID 12851811, compound

Procedure

1-Amino-2-(2-methylphenyl)ethane and 2-chlorobenzoyl chloride were reacted in the same way as in step (a) of Example 1 to afford 1-(2-chlorobenzoyl)amino-2-(2-methylphenyl)ethane having a melting point of 90.4° to 90.9° C. The product was successively reacted in the same way as in steps (b), (c), (d) and (e) to afford 1-(2-chlorophenyl)isoquinoline-5-acetonitrile having a melting point of 112.8° to 113.3° C.

Sources & evidence

ORD record: ord-2df3f134841244d289f4f557e488bf22
Source dataset: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04337256

Reaction notes

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