Trifluoroacetic acid → Z-Tyr-(D)-Gln-Gly-MePhe-NHNHCSNH2

Participants

Reaction Steps

0.60 g of BOC-(D)-Gln-Gly-MePhe-NHNHCSNH2 is treated with trifluoroacetic acid and dissolved in 10 ml of DMF. The solution is neutralized with 0.19 ml of TEA, and 0.54 g of Z-Tyr ONB is added. The mixture is stirred for 15 hours. The DMF is distilled off and the residue is treated with ethyl acetate and filtered to obtain a powder, which is further reprecipitated from methanol-ether. Yield 0.54 g; m.p. 128°-133° C.; [α]D24 -72.4° (c=1.1, DMF); Rf1 0.13.

Provenance & Evidence