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HRID1156950

反应详情

EQUATION

反应方程式

HRID 1156950 的结构方程式

REACTANTS

反应物

3
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：O=C(N[C@@H](Cc1ccc(O)cc1)C(=O)O)OCc1ccccc1
HCID712438

Carbobenzoxy-L-tyrosine

C17H17NO5

结构：CN(C(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)OC(C)(C)C)[C@@H](Cc1ccccc1)C(=O)NNC(N)=S
HCID12802637

未命名化合物

PRODUCTS

生成物

1
结构：CN(C(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OCc1ccccc1)[C@@H](Cc1ccccc1)C(=O)NNC(N)=S
HCID12802639

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

0.60 g of BOC-(D)-Gln-Gly-MePhe-NHNHCSNH2 is treated with trifluoroacetic acid and dissolved in 10 ml of DMF. The solution is neutralized with 0.19 ml of TEA, and 0.54 g of Z-Tyr ONB is added. The mixture is stirred for 15 hours. The DMF is distilled off and the residue is treated with ethyl acetate and filtered to obtain a powder, which is further reprecipitated from methanol-ether. Yield 0.54 g; m.p. 128°-133° C.; [α]D24 -72.4° (c=1.1, DMF); Rf1 0.13.

WORKUP

后处理

  1. additionis added
  2. distillationThe DMF is distilled off
  3. additionthe residue is treated with ethyl acetate
  4. filtrationfiltered
  5. customto obtain a powder, which
  6. customis further reprecipitated from methanol-ether