Sodium Hydroxide → HCID 12899266, compound

HRID 1157006Notes

Reaction equation

HRID 1157006 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[C:11]([F:12])=[CH:10][CH:9]=[CH:8][C:7]=1[SH:13])=[O:4].[OH-].[Na+]>>[F:12][C:11]1[C:6]2[NH:5][C:3](=[O:4])[CH2:2][S:13][C:7]=2[CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 12899265HCID 12899265, compound

Product 1

HCID 12899266HCID 12899266, compoundYield 89.9%

Conditions

Temperature
25 °C

Procedure

2-Chloroacetylamino-3-fluorothiophenol (2.0 g) was added to 2 N aqueous sodium hydroxide solution (25 ml), followed by stirring at room temperature (25° C.) for 3 hours. The precipitated crystals were filtered, washed with water and dried to obtain 1.5 g of the objective 5-fluoro-2,3-dihydro-1,4-benzothiazine-3-one (m.p. 190°-191° C.).

Workup

  1. filtrationThe precipitated crystals were filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-8ebdce678a414d73b98fb22d54e67ec6
Source dataset
uspto-grants-1982_06
Patent number
US04337357

Reaction notes

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