Methyl vinyl ketone → HCID 12806954, compound

HRID 1157028Notes

Reaction equation

HRID 1157028 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][CH:7]([CH2:13][CH3:14])[C:8]2=[O:12])=[CH:4][C:3]=1[O:15][CH2:16][C:17]([O:19][CH3:20])=[O:18].C([C:23]([CH3:25])=[O:24])=C.O1CC[CH2:28][CH2:27]1>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][C:7]([CH2:27][CH3:28])([CH2:13][CH2:14][C:23](=[O:24])[CH3:25])[C:8]2=[O:12])=[CH:4][C:3]=1[O:15][CH2:16][C:17]([O:19][CH3:20])=[O:18]

Participants

4

Reactant 3

HCID 6570Methyl vinyl ketone2×HCID 8028TetrahydrofuranHCID 13613301Methyl (1-oxo-2-ethyl-6,7-dichloro-5-indanyloxy)acetate

Product 1

HCID 12806954HCID 12806954, compound

Procedure

Methyl [(6,7-dichloro-2-ethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]acetate (15.8 gm., 0.05 mole) is suspended in dry tetrahydrofuran (100 ml.) containing trition-B (1 ml.). The suspension is stirred at ambient temperature and methyl vinyl ketone (5.02 gm., 0.072 mole) is added. The solution which becomes warm initially, is stirred at ambient temperature for 4 hours. Then, the stirring solution is treated with methyl vinyl ketone (0.3 ml.) and triton-B (0.6 ml.) every 4 hours for the next twenty hours.

Workup

  1. additioncontaining trition-B (1 ml.)
  2. temperatureThe solution which becomes warm initially
  3. stirringis stirred at ambient temperature for 4 hours

Sources & evidence

ORD record
ord-4ce21ad2825f41c9b9806b7bd1f8fc2a
Source dataset
uspto-grants-1982_06
Patent number
US04337354

Reaction notes

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