Methyl vinyl ketone → HCID 13613306, compound

HRID 1157029Notes

Reaction equation

HRID 1157029 reaction equation
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][CH:7]([CH:13]([CH3:15])[CH3:14])[C:8]2=[O:12])=[CH:4][C:3]=1[O:16][CH2:17][C:18]([O:20][CH3:21])=[O:19].[CH:22]([C:24]([CH3:26])=[O:25])=[CH2:23]>O1CCCC1>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]2[C:5]([CH2:6][C:7]([CH:13]([CH3:14])[CH3:15])([CH2:23][CH2:22][C:24](=[O:25])[CH3:26])[C:8]2=[O:12])=[CH:4][C:3]=1[O:16][CH2:17][C:18]([O:20][CH3:21])=[O:19]

Participants

4

Reactant 2

HCID 6570Methyl vinyl ketone2×HCID 13613303HCID 13613303, compound

Product 1

HCID 13613306HCID 13613306, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Methyl [(6,7-dichloro-2-isopropyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]acetate (16.5 gm., 0.05 mole) is suspended in dry tetrahydrofuran (100 ml.) containing triton-B (1 ml.). The suspension is stirred at ambient temperature and methyl vinyl ketone (5.02 gm., 0.072 mole) is added. The solution which becomes warm initially, is stirred at ambient temperature for 4 hours. Then, the stirring solution is treated with methyl vinyl ketone (0.3 ml.) and triton-B (0.6 ml.) every 4 hours for the next twenty hours.

Workup

  1. additioncontaining triton-B (1 ml.)
  2. temperatureThe solution which becomes warm initially
  3. stirringis stirred at ambient temperature for 4 hours

Sources & evidence

ORD record
ord-d07599ca66bb419495543d179d5ea601
Source dataset
uspto-grants-1982_06
Patent number
US04337354

Reaction notes

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