HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Nitro-1-(prop-2-ynyl)-1H-imidazole → 1-(4-((2-Nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-3-(tosyloxy)propan-2-yl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Nitro-1-(prop-2-ynyl)-1H-imidazole | HCID 54675143 | — |
| Reactant | 1-Azido-3-(tosyloxy)propan-2-yl acetate | HCID 57540208 | — |
| Product | 1-(4-((2-Nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-3-(tosyloxy)propan-2-yl acetate | HCID 59511047 | — |
Reaction Steps
2-Nitro-1-(prop-2-ynyl)-1H-imidazole 10 (0.2 g, 1.32 mmol) is heated with 1-azido-3-(tosyloxy)propan-2-yl acetate 15 (0.41 g, 1.32 mmol) at 60° C. overnight. The residue is purified by chromatography on silica gel (MeOH/CH2Cl2, 1:10) to afford 16.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07807394B2 |
| Source dataset | uspto-grants-2010_10 |
| ORD ID | ord-76352d8b2b2a424e844950bb39d98cd1 |
| Source note | uspto-grants-2010_10 |