HCID 178439407, compound → Phenol, 4-amino-2-(1-methylethyl)- (9CI)

HRID 1157159Notes

Reaction equation

HRID 1157159 reaction equation
[CH:1]([C:4]1[C:5](=[O:12])[CH:6]=[CH:7][C:8](=[N:10]O)[CH:9]=1)([CH3:3])[CH3:2]>CO>[NH2:10][C:8]1[CH:7]=[CH:6][C:5]([OH:12])=[C:4]([CH:1]([CH3:3])[CH3:2])[CH:9]=1

Participants

3

Reactant 1

HCID 178439407HCID 178439407, compound

Product 1

HCID 586009Phenol, 4-amino-2-(1-methylethyl)- (9CI)Yield 76%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-isopropyl-[1,4]benzoquinone 4-oxime (1.1 g, 6.7 mmol) in methanol was added catalytic amount of Ra/Ni complex. The reaction was stirred under 50 psi H2 atmosphere for 5 hrs and filtered through celite. The filtrate was concentrated to give 4-amino-2-isopropyl-phenol (762 mg, 76%)

Workup

  1. filtrationfiltered through celite
  2. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-cfa465a89aac446dbffa6ded69f5d7d8
Source dataset
uspto-grants-2010_10
Patent number
US07807672B2

Reaction notes

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