tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate → HCID 131728352, compound

HRID 1157182Notes

Reaction equation

HRID 1157182 reaction equation
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:20][CH2:19][N:18]([C:21]2[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][N:22]=2)[CH2:17][CH2:16]1)=O)(C)(C)C>C(Cl)Cl>[ClH:1].[N+:27]([C:24]1[CH:25]=[CH:26][C:21]([N:18]2[CH2:17][CH2:16][NH:15][CH2:20][CH2:19]2)=[N:22][CH:23]=1)([O-:29])=[O:28].[ClH:1]

Participants

4

Reactant 2

HCID 16217943tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylateHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 131728352HCID 131728352, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Added 4M HCl/dioxane (15 ml) to a solution of 4-(5-Nitro-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (2.3 g, 7.46 mmol) in MeCl2 (20 ml) at room temperature. Reaction was stirred for 3 hours and solvent was evaporated yielding the product as hydrochloride salt 1-(5-Nitro-pyridin-2-yl)-piperazine hydrochloride 8 (2.2 g)

Workup

  1. customReaction
  2. customsolvent was evaporated

Sources & evidence

ORD record
ord-9c1a227827d7481e94487d57fab3f29a
Source dataset
uspto-grants-2010_10
Patent number
US07807672B2

Reaction notes

Loading…