Hydrochloric Acid → 3-[6-Amino-1-hexyl-oxy]-pyridine, hydrochloride

HRID 1157364Notes

Reaction equation

HRID 1157364 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1)=O)(C)(C)C.[ClH:22]>C(OCC)C>[ClH:22].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68677158HCID 68677158, compound

Product 1

HCID 1317266993-[6-Amino-1-hexyl-oxy]-pyridine, hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

3-[6-(N-tert-Butoxycarbonylamino)-1-hexyl-oxy]-pyridine (180 mg) was treated with a large excess of hydrogen chloride in dietyl ether with stirring for 45 minutes followed by evaporation in vacuo. Trituration with diethyl ether, decantation and evaporation gave the title compound as a colourless powder.

Workup

  1. customfollowed by evaporation in vacuo
  2. customTrituration with diethyl ether, decantation and evaporation

Sources & evidence

ORD record
ord-e079649b816d469cb03d2c0ceca5b089
Source dataset
uspto-grants-2010_10
Patent number
US07807682B2

Reaction notes

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