Hydrochloric Acid → HCID 68678881, compound

HRID 1157367Notes

Reaction equation

HRID 1157367 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]1[CH:25]=[CH:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=1)=O)(C)(C)C.Cl.[OH-].[Na+]>C(OCC)C.O>[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][O:15][C:16]1[CH:25]=[CH:24][C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[N:17]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68678765HCID 68678765, compound

Product 1

HCID 68678881HCID 68678881, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

2-[6-(N-tert-Butoxycarbonylamino)-1-hexyl-oxy]-quinoline (480 mg) was treated with a large excess of hydrogen chloride in dietyl ether with stirring for 1 hour at room temperature. The crystalline product was isolated by filtration and redissolved in water whereafter the solution was made strongly alkaline with sodium hydroxide and extracted twice with chloroform. The organic phase was dried over potassium carbonate, filtered and evaporated to yield the title compound as a colourless oil.

Workup

  1. customThe crystalline product was isolated by filtration
  2. extractionextracted twice with chloroform
  3. dry with materialThe organic phase was dried over potassium carbonate
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-2a5c3e79ee6e43efb26a2cbb20236601
Source dataset
uspto-grants-2010_10
Patent number
US07807682B2

Reaction notes

Loading…