HRID1157598

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID31268

Pyrrolidine

C4H9N

结构：O=C(Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc(Cl)c(OCCCl)c3)n2)c1)C(F)(F)F

HCID57737180

未命名化合物

PRODUCTS

生成物

结构：Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3ccc(Cl)c(OCCN4CCCC4)c3)n2)c1

HCID57737228

未命名化合物

收率 50%

PROCEDURE

实验过程

The compound was synthesized from N-(3-{3-[2-({4-chloro-3-[(2-chloroethyl)oxy]phenyl}amino)-4-pyrimidinyl]pyrazolo[1,5-a]pyridin-2-yl}phenyl)-2,2,2-trifluoroacetamide and pyrrolidine using procedure outlined in Example 10, Step D, to afford a solid in 50% yield. ES-LC/MS m/z 526-[M+H]+.

WORKUP

后处理

customto afford a solid in 50% yield

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e225a31cb9604cf994bfeb6d1542f948
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07807673B2
来源说明: uspto-grants-2010_10

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:14]=[C:13]([C:15]3[C:16]([C:24]4[CH:25]=[C:26]([NH:30]C(=O)C(F)(F)F)[CH:27]=[CH:28][CH:29]=4)=[N:17][N:18]4[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=34)[CH:12]=[CH:11][N:10]=2)=[CH:4][C:3]=1[O:37][CH2:38][CH2:39]Cl.[NH:41]1[CH2:45][CH2:44][CH2:43][CH2:42]1>>[NH2:30][C:26]1[CH:25]=[C:24]([C:16]2[C:15]([C:13]3[CH:12]=[CH:11][N:10]=[C:9]([NH:8][C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([O:37][CH2:38][CH2:39][N:41]5[CH2:45][CH2:44][CH2:43][CH2:42]5)[CH:4]=4)[N:14]=3)=[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][N:18]3[N:17]=2)[CH:29]=[CH:28][CH:27]=1