HRID1157617

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C(Cc1cccs1)Nc1cccc(-c2nn3ccccc3c2-c2ccnc(Nc3cccc(-c4cnco4)c3)n2)c1

HCID57737194

未命名化合物

HCID59511420

未命名化合物

PRODUCTS

生成物

结构：Cc1ncoc1-c1cccc(Nc2nccc(-c3c(-c4cccc(NC(=O)Cc5cccs5)c4)nn4ccccc34)n2)c1

HCID16749909

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized from N-{3-[3-(2-chloro-4-pyrimidinyl)pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2-(2-thienyl)acetamide (see Example 2, step B) and 3-(4-methyl-1,3-oxazol-5-yl)aniline following the protocol described in Example 2, step E. The reaction formed a suspension on cooling to rt. The suspension was filtered and provided the title compound in 81% yield.

WORKUP

后处理

customThe reaction formed a suspension
filtrationThe suspension was filtered

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5f972687d7ed480aaf9512411bdccbb6
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07807673B2
来源说明: uspto-grants-2010_10

反应 SMILES

[O:1]1[C:5]([C:6]2[CH:7]=[C:8]([NH:12][C:13]3[N:18]=[C:17]([C:19]4[C:20]([C:28]5[CH:29]=[C:30]([NH:34][C:35](=[O:42])[CH2:36][C:37]6[S:38][CH:39]=[CH:40][CH:41]=6)[CH:31]=[CH:32][CH:33]=5)=[N:21][N:22]5[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=45)[CH:16]=[CH:15][N:14]=3)[CH:9]=[CH:10][CH:11]=2)=[CH:4][N:3]=[CH:2]1.[CH3:43]C1N=COC=1C1C=C(C=CC=1)N>>[CH3:43][C:4]1[N:3]=[CH:2][O:1][C:5]=1[C:6]1[CH:7]=[C:8]([NH:12][C:13]2[N:18]=[C:17]([C:19]3[C:20]([C:28]4[CH:29]=[C:30]([NH:34][C:35](=[O:42])[CH2:36][C:37]5[S:38][CH:39]=[CH:40][CH:41]=5)[CH:31]=[CH:32][CH:33]=4)=[N:21][N:22]4[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=34)[CH:16]=[CH:15][N:14]=2)[CH:9]=[CH:10][CH:11]=1