Hydrogen Bromide → HCID 68643676, compound

HRID 1157686Notes

Reaction equation

HRID 1157686 reaction equation
[CH3:1][CH:2]1[C:11]2[C:6](=[CH:7][C:8]([NH:12]C(=O)OC)=[CH:9][CH:10]=2)[CH2:5][CH2:4][N:3]1[CH3:17].[BrH:18]>C(O)(=O)C>[BrH:18].[NH2:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[CH:2]([CH3:1])[N:3]([CH3:17])[CH2:4][CH2:5]2

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 86620648HCID 86620648, compound

Product 1

HCID 68643676HCID 68643676, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

A mixture of 110 mg (0.47 mmol) methyl (1,2-dimethyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-carbamate, 2.0 MI 33% HBr in glacial acetic acid and 2.0 ml glacial acetic acid are heated to boiling for 1.5 h. Then the mixture is concentrated in vacuo, mixed with water and the aqueous phase is separated off and freeze-dried.

Workup

  1. temperatureare heated
  2. concentrationThen the mixture is concentrated in vacuo
  3. additionmixed with water
  4. customthe aqueous phase is separated off
  5. customfreeze-dried

Sources & evidence

ORD record
ord-158bfbc6b2b1489993412750d8410460
Source dataset
uspto-grants-2010_10
Patent number
US07807693B2

Reaction notes

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